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American Society of Hematology, Blood, 6(126), p. 817-824, 2015

DOI: 10.1182/blood-2015-02-628594

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Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach

Journal article published in 2015 by Jordan C. Ciciliano, Yumiko Sakurai, David R. Myers, Meredith E. Fay, Beatrice Hechler, Shannon Meeks, Renhao Li, J. Brandon Dixon, L. Andrew Lyon ORCID, Christian Gachet, Wilbur A. Lam
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points The multivariate mechanism of FeCl3-induced thrombosis is rooted in colloidal chemistry, mass transfer, and biological clotting. FeCl3-induced thrombosis is mediated by charge-based binding of proteins (cell surface bound and soluble) to the Fe3+ ion.