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American Society for Cell Biology, Molecular Biology of the Cell, 23(20), p. 4976-4984

DOI: 10.1091/mbc.e09-04-0295

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Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells

Journal article published in 2009 by Sabrina Fritah ORCID, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, Susanna Chiocca, Elisabeth Christians, Saadi Khochbin, Caroline Jolly, Claire Vourc'h
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock–dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.