Published in

The Royal Society, Biology Letters, 5(6), p. 666-668, 2010

DOI: 10.1098/rsbl.2010.0329

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Disease association mapping in Drosophila can be replicated in the wild

Journal article published in 2010 by Lena Wilfert ORCID, Francis M. Jiggins ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Association and linkage mapping have become important tools in understanding the genetics of complex traits, including diseases in humans. As the success of association mapping is reduced by small effect sizes and limited power, linkage studies in laboratory-based model systems are still heavily used. But whether the results of these studies can be replicated in natural populations has been questioned. Here, we show that a polymorphism in the gene ref ( 2 ) P , which had previously been linked to sigma virus resistance in Drosophila melanogaster under laboratory conditions, also provides resistance against the virus in female flies in a wild population in the field. This genetic association is thus upheld in spite of a known genotype-by-genotype interaction and environmental variation.