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Public Library of Science, PLoS ONE, 9(5), p. e12589, 2010

DOI: 10.1371/journal.pone.0012589

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Pathophysiological Mechanisms of Severe Anaemia in Malawian Children

Journal article published in 2010 by Michaël Boele van Hensbroek, Michael Boele van Hensbroek, Job C. J. Calis, Kamija S. Phiri ORCID, Raymond Vet, Francis Munthali, Rob Kraaijenhagen, Henk van den Berg, Brian Faragher, Imelda Bates ORCID, Malcolm E. Molyneux
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: Severe anaemia is a major cause of morbidity and mortality in African children. The aetiology is multi-factorial, but interventions have often targeted only one or a few causal factors, with limited success. METHODS AND FINDINGS: We assessed the contribution of different pathophysiological mechanisms (red cell production failure [RCPF], haemolysis and blood loss) to severe anaemia in Malawian children in whom etiological factors have been described previously. More complex associations between etiological factors and the mechanisms were explored using structural equation modelling. In 235 children with severe anaemia (haemoglobin