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The Royal Society, Philosophical Transactions of the Royal Society B: Biological Sciences, 1459(360), p. 1411-1425, 2005

DOI: 10.1098/rstb.2005.1667

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Theoretical models of selection and mutation on quantitative traits

Journal article published in 2005 by Toby Johnson ORCID, Nick Barton
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Empirical studies of quantitative genetic variation have revealed robust patterns that are observed both across traits and across species. However, these patterns have no compelling explanation, and some of the observations even appear to be mutually incompatible. We review and extend a major class of theoretical models, ‘mutation–selection models’, that have been proposed to explain quantitative genetic variation. We also briefly review an alternative class of ‘balancing selection models’. We consider to what extent the models are compatible with the general observations, and argue that a key issue is understanding and modelling pleiotropy. We discuss some of the thorny issues that arise when formulating models that describe many traits simultaneously.