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American Diabetes Association, Diabetes Care, 3(31), p. 514-516, 2008

DOI: 10.2337/dc07-1399

American Diabetes Association, Diabetes Care, 7(31), p. e60-e60, 2008

DOI: 10.2337/dc08-0676

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Cognitive Function in Children and Subsequent Type 2 Diabetes

Journal article published in 2007 by Gunilla M. Olsson, Anna-Lena Hulting, Scott M. Montgomery ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVE—To assess whether a diagnosis of type 2 diabetes by age 42 years is associated with prior cognitive deficits in childhood. RESEARCH DESIGN AND METHODS—Logistic regression estimated type 2 diabetes risk among 9,113 members of the 1958 British birth cohort of the National Child Development Study (NCDS). Associations with type 2 diabetes were estimated for general ability and reading comprehension assessments at age 11 years, modeled using SD units. Adjustment was for markers of early-life exposures, social and material family characteristics, sex, and disability, with further adjustment for BMI at age 7 years. RESULTS—Adjusted odds ratios (95% CIs) for type 2 diabetes (n = 69) are 0.67 (0.51–0.87) for general ability and 0.58 (0.44–0.77) for reading comprehension. Neither additional adjustment for BMI, nor limiting the definition of type 2 diabetes to onset after age 33 years altered the associations substantially. CONCLUSIONS—Impaired cognitive function may precede clinical onset of type 2 diabetes.