Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial

von Seidlein, Lorenz; Olaosebikan, Rasaq; Hendriksen, Ilse C. E.; Lee, Sue J.; Adedoyin, Olanrewaju Timothy; Agbenyega, Tsiri; Nguah, Samuel Blay; Bojang, Kalifa; Deen, Jacqueline L.; Evans, Jennifer; Fanello, Caterina I.; Gomes, Ermelinda; Pedro, Alínia José; Kahabuka, Catherine; Karema, Corine; Kivaya, Esther; Maitland, Kathryn; Mokuolu, Olugbenga A.; Mtove, George; Mwanga-Amumpaire, Juliet; Nadjm, Behzad; Nansumba, Margaret; Ngum, Wirichada Pan; Onyamboko, Marie A.; Reyburn, Hugh; Sakulthaew, Tharisara; Silamut, Kamolrat; Tshefu, Antoinette K.; Umulisa, Noella; Gesase, Samwel; Day, Nicholas P. J.; White, Nicholas J.; Dondorp, Arjen M.

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Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial

Journal article published in 2012 by Lorenz von Seidlein, Rasaq Olaosebikan, Ilse C. E. Hendriksen, Sue J. Lee, Olanrewaju Timothy Adedoyin, Tsiri Agbenyega, Samuel Blay Nguah, Kalifa Bojang, Jacqueline L. Deen, Jennifer Evans, Caterina I. Fanello, Ermelinda Gomes, Alínia José Pedro, Catherine Kahabuka, Corine Karema and other authors.

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Abstract

Four predictors were independently associated with an increased risk of death: acidosis, cerebral manifestations of malaria, elevated blood urea nitrogen, or signs of chronic illness. The standard base deficit was found to be the single most relevant predictor of death.