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American Chemical Society, Organic Letters, 18(17), p. 4468-4471, 2015

DOI: 10.1021/acs.orglett.5b02132

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Dipeptide nanotubes containing unnatural fluorine-substituted β(2,3)-diarylamino acid and l-Alanine as candidates for biomedical applications

Journal article published in 2015 by Andrea Bonetti, Sara Pellegrino ORCID, Priyadip Das, Sivan Yuran, Raffaella Bucci, Nicola Ferri ORCID, Fiorella Meneghetti, Carlo Castellano ORCID, Meital Reches, Maria Luisa Gelmi
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β(2,3)-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.