Published in
Portland Press, Biochemical Journal, 1(467), p. 47-62, 2015
DOI: 10.1042/bj20141441
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The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner
Journal article published in 2015 by
Fiona P. Bailey,
Dominic P. Byrne,
Krishnadev Oruganty,
Claire E. Eyers 
,
Christopher J. Novotny,
Kevan M. Shokat,
Natarajan Kannan,
Patrick A. Eyers
,
Christopher J. Novotny,
Kevan M. Shokat,
Natarajan Kannan,
Patrick A. Eyers
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Abstract
We report that Tribbles 2 (TRB2), a pseudokinase linked to cancer, binds ATP and autophosphorylates in a metal-independent manner. This activity is prevented by mutations in the ATP-binding site and a TRB2 mutant can be targeted with a small molecule ligand.