Published in
Portland Press, Biochemical Journal, 3(467), p. 495-505, 2015
DOI: 10.1042/bj20141291
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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
Journal article published in 2015 by
Aisha Shamas-Din,
Scott Bindner,
Xiaoke Chi,
Brian Leber,
David W Andrews 
,
Cécile Fradin
,
Cécile Fradin
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Abstract
tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL), like Mtch2, promotes the activating conformational change of tBid.