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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(58), p. 2948-2951, 2014

DOI: 10.1128/aac.02755-13

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Pharmacokinetics of Ofloxacin and Levofloxacin for Prevention and Treatment of Multidrug-Resistant Tuberculosis in Children

Journal article published in 2014 by S. Thee ORCID, A. J. Garcia-Prats, H. M. McIlleron, L. Wiesner, S. Castel, J. Norman, H. R. Draper, P. L. van der Merwe, A. C. Hesseling, H. S. Schaaf
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Limited data on fluoroquinolone pharmacokinetics and cardiac effects in children exist. Among 22 children receiving drug-resistant tuberculosis prophylaxis or treatment, serum concentrations following oral doses of levofloxacin (15 mg/kg of body weight) and ofloxacin (20 mg/kg) were lower than those expected from existing pediatric data, possibly due to differences in the formulations (crushed tablets). Drug exposures were lower than those in adults following standard doses and below the proposed pharmacodynamic targets, likely due to more rapid elimination in children. No QT prolongation was observed.