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National Academy of Sciences, Proceedings of the National Academy of Sciences, 15(111), p. 5694-5699, 2014

DOI: 10.1073/pnas.1322678111

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Global dissemination of a multidrug resistant Escherichia coli clone

Journal article published in 2014 by Nicola K. Petty, N. L. B. Zakour, Nouri L. Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M. Forde, Minh-Duy Phan, Danilo Gomes Moriel, Kate M. Peters, Mark Davies, Benjamin A. Rogers, Gordon Dougan, Jesús Rodriguez-Baño, Alvaro Pascual ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Escherichia coli sequence type 131 (ST131) is a globally disseminated multidrug-resistant clone associated with human urinary tract and bloodstream infections. Here, we have used genome sequencing to map the temporal and spatial relationship of a large collection of E. coli ST131 strains isolated from six distinct geographical regions across the world. We show that E. coli ST131 strains are distinct from other extraintestinal pathogenic E. coli and arose from a single progenitor strain prior to the year 2000.