American Society for Microbiology, Journal of Bacteriology, 15(186), p. 4861-4861, 2004
DOI: 10.1128/jb.186.15.4861.2004
American Society for Microbiology, Journal of Bacteriology, 15(186), p. 4862-4863, 2004
DOI: 10.1128/jb.186.15.4862-4863.2004
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Roth's and Andersson's model (12) supports the conserva- tive neo-Darwinist precept of constant and gradual evolution- ary change. They exclude the possibility that mutation rates (per base pair replicated) may be affected by environmental stress (and are thus forced to argue the unimportance of those cells with demonstrably increased mutation rates). However, their model requires that we ignore much important data that contradict it; moreover, the data that they cite do not really support their conclusions. Here, space allows us to point out just a few such instances. First, the quantification of their model requires that they diverge from commonly accepted values both for mutation rate and amplification copy number. To generate 100 Lac point mutant colonies per 10 8 cells plated by day 5, they propose that 10 2 of the cells plated (10 6 cells) carry a preexisting gene