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Elsevier, Neurobiology of Aging, 2(29), p. 314-316

DOI: 10.1016/j.neurobiolaging.2006.10.008

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Absence of angiogenic genes modification in Italian ALS patients

Journal article published in 2008 by Roberto Del Bo, Marina Scarlato, Serena Ghezzi, S. Grezzi, Filippo Martinelli-Boneschi ORCID, Stefania Corti ORCID, Federica Locatelli, A. Pelle, Domenico Santoro, Alessandro Prelle, Chiara Briani, M. Cardini, Martina Nardini, Gabriele Siciliano, Michelangelo Mancuso and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently distributed between patients and controls. Overall, our data argue against the hypothesis of both genes as risk factors for motoneuron neurodegeneration, at least in an Italian population.