Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 1(18), p. 309-312
DOI: 10.1016/j.bmcl.2007.10.077
Links
Tools
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Journal article published in 2008 by
Luigi Scipione 
,
Daniela De Vita,
Alessandra Musella,
Lisa Flammini,
Simona Bertoni,
Elisabetta Barocelli
,
Daniela De Vita,
Alessandra Musella,
Lisa Flammini,
Simona Bertoni,
Elisabetta Barocelli
This paper was not found in any repository, but could be made available legally by the author.
Full text: Unavailable
Postprint:
archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.