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Public Library of Science, PLoS Biology, 1(9), p. e1000580

DOI: 10.1371/journal.pbio.1000580

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Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.