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Public Library of Science, PLoS Biology, 1(9), p. e1000580, 2011

DOI: 10.1371/journal.pbio.1000580

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Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Journal article published in 2011 by Carl A. Anderson, Nicole Soranzo, Eleftheria Zeggini ORCID, Jeffrey C. Barrett ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.