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Nature Research, Nature Neuroscience, 1(17), p. 27-29, 2013

DOI: 10.1038/nn.3591

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Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Journal article published in 2013 by Jessica J. Walsh, Allyson K. Friedman, Haosheng Sun, Elizabeth A. Heller, Stacy M. Ku, Barbara Juarez ORCID, Veronica L. Burnham, Michelle S. Mazei-Robison ORCID, Deveroux Ferguson, Sam A. Golden, Ja Wook Koo, Dipesh Chaudhury, Daniel J. Christoffel, Lisa Pomeranz, Jeffrey M. Friedman and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.