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Hindawi, PPAR Research, (2012), p. 1-9, 2012

DOI: 10.1155/2012/164140

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Coordinated Regulation of PPAR Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

Journal article published in 2012 by Jérôme Eeckhoute ORCID, Frédérik Oger, Bart Staels, Philippe Lefebvre ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes. Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells. Here, we review findings indicating that PPARγ expression and activity are intricately regulated through control of chromatin structure. Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPARγ and its target genes through sequential chromatin remodelling. In obesity, these regulatory pathways may be altered and lead to modified PPARγ activity.