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Cell Press, Cell Metabolism, 6(15), p. 795-797, 2012
DOI: 10.1016/j.cmet.2012.05.007
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Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.
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Abstract
The ChREBP transcription factor is regulated by glucose and plays a role in insulin sensitivity, but the mechanism underlying these effects remains unclear. In a recent Nature article, Herman et al. (2012) show that a shorter ChREBP isoform (ChREBP-β) links glucose transport to lipogenesis in white adipose tissue.