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BioMed Central, BMC Neuroscience, S2(9), 2008

DOI: 10.1186/1471-2202-9-s2-s6

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Therapeutic potential of resveratrol in Alzheimer's disease

Journal article published in 2008 by Davies Peter, Valérie Vingtdeux ORCID, Haitian Zhao, Ute Dreses-Werringloer, Philippe Marambaud
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with potential neuroprotective activities. Despite scepticism concerning the bioavailability of these polyphenols, in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases. Furthermore, recent work in cell cultures and animal models has shed light on the molecular mechanisms potentially involved in the beneficial effects of resveratrol intake against the neurodegenerative process in Alzheimer's disease.