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Springer, Journal of NeuroVirology, 5(18), p. 423-427, 2012

DOI: 10.1007/s13365-012-0115-0

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Brain structural and functional recovery following initiation of combination antiretroviral therapy

Journal article published in 2012 by James T. Becker ORCID, Pablo Cuesta, Melissa Fabrizio, Gustavo Sudre, Emanuel N. Vergis, Antoine Douaihy, Ricardo Bajo, Allie Schubert, Oscar L. Lopez, Lauri Parkkonen, Fernando Maestu, Anto Bagic
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This paper is available in a repository.

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Abstract

NeuroAIDS persists in the era of cART. We describe here recovery of brain structure and function following after 6 months of therapy in a treatment-naïve patient presenting with HIV-Associated Dementia. The patient's neuropsychological test performance improved, and his total brain volume increased by more than 5%. Neuronal functional connectivity measured by magnetoencephalography changed from a pattern identical to that observed in other HIV-infected individuals, to one that was indistinguishable from that of uninfected control subjects. These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment.