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BMJ Publishing Group, Annals of the Rheumatic Diseases, 6(71), p. 961-965, 2011

DOI: 10.1136/annrheumdis-2011-200182

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Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study

Journal article published in 2011 by H. Chinoy, S. Adimulam, F. Marriage, P. New, M. Vincze, E. Zilahi, A. Kapitány, A. Gyetvai, L. Ekholm, P. Novota, M. Remakova, P. Charles, N. J. McHugh, L. Padyukov ORCID, L. Alfredsson and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVES: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM.METHODS: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation.RESULTS: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1-positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p