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Public Library of Science, PLoS ONE, 6(7), p. e38628, 2012

DOI: 10.1371/journal.pone.0038628

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Naturally-Acquired Influenza-Specific CD4+ T-Cell Proliferative Responses Are Impaired in HIV-Infected African Adults

Journal article published in 2012 by Kondwani C. Jambo, Enoch Sepako, Sarah J. Glennie, David Mzinza ORCID, Neil A. Williams, Stephen B. Gordon, Robert S. Heyderman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.