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American Society for Microbiology, Journal of Virology, 21(79), p. 13735-13746, 2005

DOI: 10.1128/jvi.79.21.13735-13746.2005

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Human Immunodeficiency Virus Type 1 Vpr Interacts With Antiapoptotic Mitochondrial Protein Hax-1

Journal article published in 2005 by Venkat S. R. K. Yedavalli, 施修明;呂俊毅;張鑾英;陳茂源;莊哲彥;蔣官德;黃立民, VSRK; Shih HM; Chiang YP; Lu CY; Chang LY; Chen MY; Chuang CY; Dayton A; Jeang KT;Huang LM; Yedavalli, Hsiu-Ming Shih, Yu-Ping Chiang, Chun-Yi Lu ORCID, Luan-Yin Chang, Mao-Yuan Chen, Che-Yen Chuang, Andrew I. Dayton, Kuan-Teh Jeang, Li-Min Huang ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Human immunodeficiency virus type 1 viral protein R (Vpr) is required for viral pathogenesis and has been implicated in T-cell apoptosis through its activation of caspase 3 and caspase 9 and perturbation of mitochondrial membrane potential. To understand better Vpr-mitochondria interaction , we report here the identification of antiapoptotic mitochondrial protein HAX-1 as a novel Vpr target. We show that Vpr and HAX-1 physically associate with each other. Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr. ; 附設醫院小兒部 ; 醫學院附設醫院 ; 期刊論文