Published in

Elsevier, Digestive and Liver Disease, 7(44), p. 585-588

DOI: 10.1016/j.dld.2011.12.019

Links

Tools

Export citation

Search in Google Scholar

“PancPro” as a tool for selecting families eligible for pancreatic cancer screening: An Italian study of incident cases

Journal article published in 2012 by Giulia Leonardi, Santino Marchi, Massimo Falconi, Alessandro Zerbi, Nicola de Bortoli ORCID, Valeria Ussia, N. D. Bortoli, Franco Mosca, Silvano Presciuttini, Marco Del Chiaro
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

BACKGROUND: PancPRO is a computer program that estimates the risk of pancreatic cancer for asymptomatic individuals based on a genetic model of susceptibility and the familial incidence of cancer. AIM: To evaluate the distribution of the familial risk in a series of incident cases of pancreatic adenocarcinoma. MATERIALS AND METHODS: The lifetime risk of pancreatic cancer was calculated by PancPro for a hypothetical 40-year-old son of 570 consecutive probands with pancreatic cancer. RESULTS: The 570 risk values were included between 1\% and 13\%. The distribution was bimodal, with the antimode located at risk=7.5\%. Considering a 10-fold risk over the general population as a threshold for including a subject in a surveillance program, 19 families (3.3\%) would be selected, totalling 92 first-degree relatives with age >40 years. CONCLUSIONS: PancPro is a valid instrument to rank families based on risk of pancreatic cancer.