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Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months’ consumption of a combination of bioactive food ingredients in overweight subjects
Journal article published in 2012 by
Mariangela Rondanelli,
Annalisa Opizzi,
Simone Perna,
Milena Faliva,
Sebastiano Bruno Solerte,
Marisa Fioravanti,
Catherine Klersy,
Edda Cava,
Paolini Maddalena,
Scavone Luciano,
Paola Ceccarelli,
E. Castellaneta,
Castellaneta Emanuela,
Savina Claudia,
Lorenzo Maria Donini 
Abstract
This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and l-carnitine) versus a placebo, as part of a therapeutic ‘lifestyle change’ diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m2) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group. We observed that consumption of the dietary supplement was associated with a significantly greater decrease in insulin resistance, assessed by homostasis model assessment (p