Springer Nature [academic journals on nature.com], Cell Research, 10(23), p. 1155-1156, 2013
DOI: 10.1038/cr.2013.103
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The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.