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Springer Nature [academic journals on nature.com], Cell Research, 10(23), p. 1155-1156, 2013

DOI: 10.1038/cr.2013.103

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Pills of PTEN? In and out for tumor suppression

Journal article published in 2013 by Antonella Papa ORCID, Ming Chen, Pier Paolo Pandolfi
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.