Elsevier, Tetrahedron Letters, 2(38), p. 277-280
DOI: 10.1016/s0040-4039(96)02291-5
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The combination of sodium borohydride and amberlyst-15 (H+) in tetrahydrofurane is a powerful reductor for unreactive ketones. The reduction is fast, high-yielding and the work-up is extremely simple. Ketals, silyl ethers and other organic functions are not disturbed during the reduction. ; This work was supported by the Spanish DGICYT (PB94-0028). JRC thanks the ICI for a predoctoral fellowship. ; Peer Reviewed