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Elsevier, Journal of Hepatology, 2(59), p. 400, 2013

DOI: 10.1016/j.jhep.2013.04.019

Elsevier, Journal of Hepatology, 1(59), p. 24-30, 2013

DOI: 10.1016/j.jhep.2013.02.015

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Mother-to-infant transmission of hepatitis B virus infection: Significance of maternal viral load and strategies for intervention

Journal article published in 2013 by ;倪衍玄 ;陳惠玲 ;張美惠 ;許宏遠 ;吳嘉峰 ;陳培哲 ;陳慧玲 陳定信, Wan-Hsin;Chang Mei-Hwei;Zhao Lu-Lu;Ni Yen-Hsuan;Hsu Hong-Yuan;Wu Jia-Feng;Chen Pei-Jer;Chen Ding-Shinn;Chen Huey-Ling Wen, Mei-Hwei Chang, Lu-Lu Zhao, Ka Wang Cheung, Yen-Hsuan Ni, Jia-Feng Wu ORCID, Mimi Tin Yan Seto, Hong-Yuan Hsu, Pei-Jer Chen ORCID, Ding-Shinn Chen, Chin Peng Lee, Huey-Ling Chen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background & Aims: Immunoprophylaxis reduces but does not completely eradicate hepatitis B virus (HBV) transmission. This prospective study aims at assessing the rate and risk factors of maternally transmitted HBV infection. Methods: We enrolled 303 mother-infant pairs with positive maternal hepatitis B surface antigen (HBsAg) under current immunization program. Maternal viral load was determined by a real-time PCR-based assay. The children were tested for HBsAg at 4-8 months and/or 1-3 years of age. Rates of HBV infection were estimated using a multivariate logistic regression model. Results: HBeAg-positive mothers (81/303, 26.7%) had higher viral loads than HBeAg-negative mothers (7.4 +/- 1.9 vs. 2.7 +/- 1.4 log(10) copies/ml, p