Published in
Public Library of Science, PLoS ONE, 2(8), p. e55916, 2013
DOI: 10.1371/journal.pone.0055916
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Longitudinal Change of HBsAg in HBeAg-negative Patients with Genotype B or C Infection
,
Tung-Hung;Liu Chun-Jen;Tseng Tai-Chung;Liu Chen-Hua;Yang Hung-Chih;Chen Chi-Ling;Chen Pei-Jer;Kao Jia-Horng;Chen Ding-Shinn Su ,
Tai-Chung Tseng,
Chen-Hua Liu,
Hung-Chih Yang,
Chi-Ling Chen,
Pei-Jer Chen ,
Jia-Horng Kao ,
Ding-Shinn Chen
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Abstract
Background & Aims: Quantitative HBsAg has been recognized to assist in the management of chronic hepatitis B virus (HBV) infection. However, its role in disease monitoring of HBeAg-negative patients remains unclear. We aimed to investigate the longitudinal HBsAg change in HBeAg-negative carriers with HBV genotype B or C infection. Methods: This is a retrospective cohort study conducted in a university hospital. Treatment-naive HBeAg-negative carriers followed for more than 3 years were recruited. Their hepatitis activities were categorized by longitudinal HBV-DNA levels into high viral-load (HVL: HBV-DNA >/=2000 IU/mL persistently), low viral-load (LVL: HBV-DNA 1000, 100-999,