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Public Library of Science, PLoS ONE, 11(8), p. e81833, 2013

DOI: 10.1371/journal.pone.0081833

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Prdm6 Is Essential for Cardiovascular Development In Vivo

Journal article published in 2013 by Andreas Gewies, Martin Hrabé de Angelis, Mercedes Castineiras-Vilarino, Uta Ferch, N. Jaehrling, Nina Jährling, Katja Heinrich, Ulrike Hoeckendorf, Gerhard K. H. Przemeck ORCID, Matthias Munding, Olaf Gross, Timm Schroeder, Marion Horsch, E. Loraine Karran, Aneela Majid and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.