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Elsevier, Methods, 2(67), p. 159-168, 2014

DOI: 10.1016/j.ymeth.2014.01.004

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Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures

This paper is available in a repository.
This paper is available in a repository.

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Abstract

In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modifications. We hope this paper will guide others as they perform similar experiments leading to more information about the effects of chemical modifications on G-quadruplex formation. The structures of tetramolecular quadruplexes and some higher order structures based on tetramolecular quadruplexes are also described.