Elsevier, Pesticide Biochemistry and Physiology, 1(107), p. 93-97
DOI: 10.1016/j.pestbp.2013.05.010
Full text: Unavailable
The aim of this study is to gain more knowledge on the impact of early life pesticide exposure on premature aging. The effect of a low dose of the insecticide permethrin administered to rats during early life (1/50 LD50, from 6th to 21st day of life) was analyzed by measuring some metabolites in plasma and urine of 500- day-old animals. Significant differences in early life treated rats compared to the control group were found in the plasma levels of Ca++, Na+, 25-hydroxy-vitamin D, adrenaline, noradrenaline, nitric oxide, cholesterol and urea while in urine only Na+ content was different. These results add information on the impact of permethrin during the neonatal period, supporting the evidence that early life environmental exposure to xenobiotics has long-term effects, inducing modifications in adulthood that can be revealed by the analysis of some macroelements, metabolites and catecholamines in plasma, when rats are 500 days old.