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BMJ Publishing Group, Annals of the Rheumatic Diseases, 9(71), p. 1448-1453, 2012

DOI: 10.1136/annrheumdis-2011-201215

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Purine-rich foods intake and recurrent gout attacks

Journal article published in 2012 by Yuqing Zhang, Clara Chen, Hyon Choi, Christine E. Chaisson, David J. Hunter, Jingbo Niu ORCID, Tuhina Neogi ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVE: To examine and quantify the relation between purine intake and the risk of recurrent gout attacks among gout patients. METHODS: The authors conducted a case-crossover study to examine associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were prospectively recruited and followed online for 1 year. Participants were asked about the following information when experiencing a gout attack: the onset date of the gout attack, clinical symptoms and signs, medications (including antigout medications), and presence of potential risk factors (including daily intake of various purine-containing food items) during the 2-day period prior to the gout attack. The same exposure information was also assessed over 2-day control periods. RESULTS: This study included 633 participants with gout. Compared with the lowest quintile of total purine intake over a 2-day period, OR of recurrent gout attacks were 1.17, 1.38, 2.21 and 4.76, respectively, with each increasing quintile (p for trend