Radiological Society of North America, Radiology, 3(267), p. 851-857
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Significantly lower N-acetylaspartate (NAA)/creatinine and NAA/choline ratios in the precentral gyrus, midfrontal region, left caudate, occipital lobe, and other regions confirm that amyotrophic lateral sclerosis is a multisystem disorder of the entire brain and is not restricted to the motor cortex.