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BioMed Central, Stem Cell Research and Therapy, 6(4), 2013

DOI: 10.1186/scrt351

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Mesenchymal stromal cells for the treatment of critical limb ischemia: context and perspective

Journal article published in 2013 by Hendrik Gremmels ORCID, Joost O. Fledderus, Martin Teraa, Marianne C. Verhaar
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic limbs. In this commentary, we discuss a recent study by Gupta and colleagues, one of the first human trials using allogeneic MSCs for CLI, in relation to the current state of knowledge regarding cell therapy for CLI.