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Elsevier, The American Journal of Pathology, 5(179), p. 2152-2156, 2011

DOI: 10.1016/j.ajpath.2011.07.021

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Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis

Journal article published in 2011 by Micha M. M. Wilhelmus, John G. J. M. Bol, Elise S. Van Haastert, Annemieke J. M. Rozemuller, Guojun Bu, Benjamin Drukarch, Jeroen J. M. Hoozemans ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Parkinson's disease (PD) is characterized by α-synuclein–containing Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.