Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 7(112), p. 2058-2063, 2015

DOI: 10.1073/pnas.1412770112

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Phylogenomics with paralogs

Journal article published in 2015 by Marc Hellmuth, Nicolas Wieseke, Marcus Lechner, Hans-Peter Lenhof, Martin Middendorf, Peter F. Stadler ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance We demonstrate that the distribution of paralogs in large gene families contains in itself sufficient phylogenetic signal to infer fully resolved species phylogenies. This source of phylogenetic information is independent of information contained in orthologous sequences and is resilient against horizontal gene transfer. An important consequence is that phylogenomics data sets need not be restricted to 1:1 orthologs.