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Nature Research, Nature Methods, 6(10), p. 524-539, 2013

DOI: 10.1038/nmeth.2482

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Imaging human connectomes at the macroscale

Journal article published in 2013 by R. Cameron Craddock, R. Cameron Craddock ORCID, Saad Jbabdi, Chao-Gan Yan, Joshua T. Vogelstein, F. Xavier Castellanos, F. Xavier Castellanos, Adriana Di Martino ORCID, Clare Kelly, Keith Heberlein, Stan Colcombe, Michael P. Milham
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

At macroscopic scales, the human connectome is composed of anatomically distinct brain areas, the structural pathways connecting them, and their functional interactions. Successful annotation of phenotypic associations with variation in the connectome and cataloguing of neurophenotypes promise to transform our understanding of the human brain. This review provides a survey of magnetic resonance imaging-based measurements of functional and structural connectivity. We highlight emerging areas of development and inquiry, and emphasize the importance of integrating structural and functional perspectives on brain architecture.