Elsevier, Heart Rhythm, 9(12), p. 1963-1971, 2015
DOI: 10.1016/j.hrthm.2015.06.007
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BACKGROUND Angiotensin-converting enzyme inhibitors (ACEIs) reduce the incidence of atrial fibrillation (AF). OBJECTIVE The purpose of this study was to assess the impact of upstream ACEI therapy on postablation AF recurrence and hospitalization in patients with low left ventricular ejection fraction (LVEF). METHODS Three hundred forty-five consecutive patients undergoing first AF ablation with low LVEF (45% undergoing first AF ablation were included for a secondary analysis to evaluate the effect of ACEI treatment in normal ejection fraction. In group 1, ACEI therapy started >= 3 months before ablation and continued through follow-up. RESULTS Baseline characteristics were similar except for hypertension, which was significantly more prevalent in ACEI+ (71 /0 vs 51%, P