A High Throughput (HT) approach is used to prepare and characterize the catalytic activity of materials for the destruction of Volatile Organic Compounds (VOC) at low temperature. The interest of the Designs of Experiments (DoE) in the primary screening is demonstrated through modeling catalysts composition according to the light-off temperature detected by infrared thermography. The combination of the mass spectrometry and the infrared thermography appears very useful to confirm and increase information about catalytic properties of the catalysts extracted to the primary screening stage. Finally, in situ Raman spectroscopy with infrared thermography allows to better understand the origin of the catalytic properties in the case of Au/CeO2 catalysts. A strong interaction between gold and Ce-O bonds leading to an improvement of the cerium oxide reducibility could explain its high reactivity for 2-propanol oxidation at lower temperature.