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Journal of Rheumatology, The Journal of Rheumatology, 6(38), p. 979-982

DOI: 10.3899/jrheum.101261

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High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis

Journal article published in 2011 by Fleur Aubart, Bruno Crestani, Pascale Nicaise-Roland, Florence Tubach, Caroline Bollet, Karen Dawidowicz, Emilie Quintin, Gilles Hayem, Elisabeth Palazzo, Olivier Meyer, Sylvie Chollet-Martin, Philippe Dieude ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Objective.To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases.Methods.A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease.Results.Male sex (OR 3.29, 95% CI 1.59–6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25–1.78) were identified as independent risk factors for lung disease in the RA population.Conclusion.High anti-CCP2 levels are associated with lung disease in the RA population.