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Public Library of Science, PLoS ONE, 7(4), p. e6176, 2009

DOI: 10.1371/journal.pone.0006176

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ProteinArchitect: Protein Evolution above the Sequence Level

Journal article published in 2009 by Matthias Haimel ORCID, Karin Pröll, Michael Rebhan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

While many authors have discussed models and tools for studying protein evolution at the sequence level, molecular function is usually mediated by complex, higher order features such as independently folding domains and linear motifs that are based on or embedded in a particular arrangment of features such as secondary structure elements, transmembrane domains and regions with intrinsic disorder. This ‘protein architecture’ can, in its most simplistic representation, be visualized as domain organization cartoons that can be used to compare proteins in terms of the order of their mostly globular domains.