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Elsevier, Bioorganic and Medicinal Chemistry Letters, 6(6), p. 653-658

DOI: 10.1016/0960-894x(96)00079-0

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Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Some analogues of the hypotensive agent caracasanamide have been synthesized and tested in vivo for cardiovascular effects. Derivative 2c emerged as the most interesting compound in the series. Structure-activity relationship is also discussed.