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Elsevier, Bioorganic and Medicinal Chemistry Letters, 3(6), p. 233-238

DOI: 10.1016/0960-894x(96)00007-8

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Caracasandiamide, a truxinic hypotensive agent from Verbesina caracasana

Journal article published in 1996 by E. GacsBaitz, Giuliano Delle Monache, G. DelleMonache, Bruno Botta ORCID, Franco Delle Monache, F. DelleMonache, Romulo Espinal, Stella C. De Bonnevaux, S. C. DeBonnevaux, Carlo De Luca, C. DeLuca, Maurizio Botta, M. Botto, Federico Corelli, Donata Dei and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A second hypotensive agent from Verbesina caracasana is shown to be the truxinic type dimer of the previously isolated 3,4-dimethoxycinnamoyl guanidinoamide. The new compound gave by alkaline hydrolysis a crystalline monoamide, which in turn by acid hydrolysis gave 3′,4′-dimethoxy-β-truxinic acid, identical with a synthetic specimen. Title compound 1 gave by alkaline hydrolysis the monoamide 2 (R = OH), which in turn by acid hydrolysis gave a β-truxinic acid 3 (R = OH), identical with a synthetic specimen.