Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Yerges-Armstrong, Lm; Wilson, Sg; Estrada, Karol; Styrkarsdottir, Unnur; Evangelou, Evangelos; Hsu, Yi-Hsiang; Wilson, Jf; Ntzani, Evangelia Ee; Oei, Ling; Van Schoor, Nm; Amin, Najaf; Tang, Nls; Zarrabeitia, Mt; Li, Guo; Liu, Ching-Ti; Moayyeri, Alireza; Vandenput, Liesbeth; Willner, Dana; Xiao, Su-Mei; Van Meurs, Jbj; Zheng, Hou-Feng; Williams, Fmk; Alonso, Nerea; Eriksson, Joel; Wood, Ar; Thorleifsson, Gudmar; Tylavsky, Fa; Van Duijn, Cm; Wareham, Nj; Uitterlinden, Ag; Duncan, El; Aalto, Ville; Alen, Markku; Albagha, Ome; Aspelund, Thor; Center, Jacqueline R.; Dailiana, Zoe; Kemp, Jp; Garcia, Melissa; Garcia-Giralt, Natalia; Giroux, Sylvie; Hallmans, Goran; Koller, Dl; Minster, Rl; Khusainova, Rita; Kammerer, Cm; Kooperberg, Charles; Koromila, Theodora; Kruk, Marcin; Kaptoge, Sk; Laaksonen, Marika; Leo, Pj; Aragaki, Ak; Lewis, Joshua R .; Masi, Laura; Mencej-Bedrac, Simona; Nogues, Xavier; Duggan, Dj; Patel, Millan S.; Prezelj, Janez; Scollen, Serena; Siggeirsdottir, Kristin; Hocking, Lj; Svensson, Olle; Trompet, Stella; Trummer, Olivia; van Schoor, Natasja M.; Woo, Jean; Zhu, Kun; Husted, Lb; Jameson, Ka; Balcells, Susana; Kim, Gs; Lacroix, Az; Cheng, Sulin; Christiansen, Claus; Lee, Sh; Cooper, Cyrus; Dedoussis, George; Ford, Ian; Frost, Morten; Leung, Pc; Goltzman, David; González-Macías, Jesus; Kähönen, Mika; Karlsson, Magnus; Khusnutdinova, Elza; Koh, Jung-Min; Kollia, Panagoula; Nguyen, Tv; Rose, Lm; Lips, Paul; Ljunggren, Osten; Smith, Av; Marc, Janja; Mellström, Dan; Obermayer-Pietsch, Barbara; Kahonen, Mika; Pettersson-Kymmer, Ulrika; Brandi, Ml; Rousseau, Francois; Lagboom, Pes Eline S.; Urreizti, Roser; Buckley, Bm; Van Hul, Wim; Viikari, Jorma; Slagboom, P. Eline; Langdahl, Bl; Leslie, Wd; Castano-Betancourt, Martha; Lorenc, Rs; Grundberg, Elin; Herrera, Lizbeth; Ingvarsson, Thorvaldur; Johannsdottir, Hrefna; Kwan, Tony; Li, Rui; Luben, Robert; Medina-Gómez, Carolina; Th Palsson, Stefan; Olmos, Jm; Reppe, Sjur; Sigurdsson, Gunnar; van Meurs, Joyce B. J.; Reid, Dm; Verlaan, Dominique; Riancho, Ja; Zhou, Yanhua; Ridker, Pm; Palsson, Stefan Th; Pastinen, Tomi; Raychaudhuri, Soumya; Aulchenko, Ys; Rotter, Ji; Cummings, Steven R.; Gautvik, Km; Danoy, Patrick; Cauley, Ja; Eastell, Richard; Chasman, Di; Gudnason, Vilmundur; Hofman, Albert; Clark, Gr; Jones, Graeme; Jukema, Jw Wouter; Dennison, Em; Khaw, Kay-Tee; Lehtimäki, Terho; Liu, Yongmei; Lorentzon, Mattias; Mccloskey, Eugene; Eisman, Ja; Nandakumar, Kannabiran; Oostra, Ben A.; Jackson, Rd; Peacock, Munro; Raitakari, Olli; Mitchell, Bd; Robbins, John; Nicholson, Gc; Pols, Hap; Prince, Rl; Reid, Ir; van Duijn, Cornelia M.; Sambrook, Pn; Sham, Pc; Cupples, La Adrienne; Shuldiner, Ar; Econs, Mj; Evans, Dm; Harris, Tb; Kung, Awc; Reeve, Jonathan; Psaty, Bm; Zillikens, Mc Carola; Thorsteinsdottir, Unnur; Spector, Td; Streeten, Ea; Ohlsson, Claes; Karasik, David; Richards, Jb Brent; Brown, Matthew A.; Stefansson, Kari; Ralston, Sh; Ioannidis, Jpa; Kiel, Dp; Hul, van Wim; Rivadeneira, Fernando

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Yerges-Armstrong et al., 2012

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@article{Yerges-Armstrong2012,
  abstract = {Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P },
  author = {Yerges-Armstrong, Lm and Wilson, Sg and Estrada, Karol and Styrkarsdottir, Unnur and Evangelou, Evangelos and Hsu, Yi-Hsiang and Wilson, Jf and Ntzani, Evangelia Ee and Oei, Ling and Van Schoor, Nm and Amin, Najaf and Tang, Nls and Zarrabeitia, Mt and Li, Guo and Liu, Ching-Ti and Moayyeri, Alireza and Vandenput, Liesbeth and Willner, Dana and Xiao, Su-Mei and Van Meurs, Jbj and Zheng, Hou-Feng and Williams, Fmk and Alonso, Nerea and Eriksson, Joel and Wood, Ar and Thorleifsson, Gudmar and Tylavsky, Fa and Van Duijn, Cm and Wareham, Nj and Uitterlinden, Ag and Duncan, El and Aalto, Ville and Alen, Markku and Albagha, Ome and Aspelund, Thor and Center, Jacqueline R. and Dailiana, Zoe and Kemp, Jp and Garcia, Melissa and Garcia-Giralt, Natalia and Giroux, Sylvie and Hallmans, Goran and Koller, Dl and Minster, Rl and Khusainova, Rita and Kammerer, Cm and Kooperberg, Charles and Koromila, Theodora and Kruk, Marcin and Kaptoge, Sk and Laaksonen, Marika and Leo, Pj and Aragaki, Ak and Lewis, Joshua R . and Masi, Laura and Mencej-Bedrac, Simona and Nogues, Xavier and Duggan, Dj and Patel, Millan S. and Prezelj, Janez and Scollen, Serena and Siggeirsdottir, Kristin and Hocking, Lj and Svensson, Olle and Trompet, Stella and Trummer, Olivia and van Schoor, Natasja M. and Woo, Jean and Zhu, Kun and Husted, Lb and Jameson, Ka and Balcells, Susana and Kim, Gs and Lacroix, Az and Cheng, Sulin and Christiansen, Claus and Lee, Sh and Cooper, Cyrus and Dedoussis, George and Ford, Ian and Frost, Morten and Leung, Pc and Goltzman, David and González-Macías, Jesus and Kähönen, Mika and Karlsson, Magnus and Khusnutdinova, Elza and Koh, Jung-Min and Kollia, Panagoula and Nguyen, Tv and Rose, Lm and Lips, Paul and Ljunggren, Osten and Smith, Av and Marc, Janja and Mellström, Dan and Obermayer-Pietsch, Barbara and Kahonen, Mika and Pettersson-Kymmer, Ulrika and Brandi, Ml and Rousseau, Francois and Lagboom, Pes Eline S. and Urreizti, Roser and Buckley, Bm and Van Hul, Wim and Viikari, Jorma and Slagboom, P. Eline and Langdahl, Bl and Leslie, Wd and Castano-Betancourt, Martha and Lorenc, Rs and Grundberg, Elin and Herrera, Lizbeth and Ingvarsson, Thorvaldur and Johannsdottir, Hrefna and Kwan, Tony and Li, Rui and Luben, Robert and Medina-Gómez, Carolina and Th Palsson, Stefan and Olmos, Jm and Reppe, Sjur and Sigurdsson, Gunnar and van Meurs, Joyce B. J. and Reid, Dm and Verlaan, Dominique and Riancho, Ja and Zhou, Yanhua and Ridker, Pm and Palsson, Stefan Th and Pastinen, Tomi and Raychaudhuri, Soumya and Aulchenko, Ys and Rotter, Ji and Cummings, Steven R. and Gautvik, Km and Danoy, Patrick and Cauley, Ja and Eastell, Richard and Chasman, Di and Gudnason, Vilmundur and Hofman, Albert and Clark, Gr and Jones, Graeme and Jukema, Jw Wouter and Dennison, Em and Khaw, Kay-Tee and Lehtimäki, Terho and Liu, Yongmei and Lorentzon, Mattias and Mccloskey, Eugene and Eisman, Ja and Nandakumar, Kannabiran and Oostra, Ben A. and Jackson, Rd and Peacock, Munro and Raitakari, Olli and Mitchell, Bd and Robbins, John and Nicholson, Gc and Pols, Hap and Prince, Rl and Reid, Ir and van Duijn, Cornelia M. and Sambrook, Pn and Sham, Pc and Cupples, La Adrienne and Shuldiner, Ar and Econs, Mj and Evans, Dm and Harris, Tb and Kung, Awc and Reeve, Jonathan and Psaty, Bm and Zillikens, Mc Carola and Thorsteinsdottir, Unnur and Spector, Td and Streeten, Ea and Ohlsson, Claes and Karasik, David and Richards, Jb Brent and Brown, Matthew A. and Stefansson, Kari and Ralston, Sh and Ioannidis, Jpa and Kiel, Dp and Hul, van Wim and Rivadeneira, Fernando},
  doi = {10.1038/ng.2249},
  month = {apr},
  title = {Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338864},
  year = {2012}
}

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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Journal article published in 2012 by Lm Yerges-Armstrong, Sg Wilson

, Karol Estrada, Unnur Styrkarsdottir, Evangelos Evangelou

, Yi-Hsiang Hsu, Jf Wilson, Evangelia Ee Ntzani, Ling Oei, Nm Van Schoor

, Najaf Amin, Nls Tang, Mt Zarrabeitia, Guo Li, Ching-Ti Liu and other authors. Lm Yerges-Armstrong, Sg Wilson

, Karol Estrada, Unnur Styrkarsdottir, Evangelos Evangelou

, Yi-Hsiang Hsu, Jf Wilson, Evangelia Ee Ntzani, Ling Oei, Nm Van Schoor

, Najaf Amin, Nls Tang, Mt Zarrabeitia, Guo Li, Ching-Ti Liu, Alireza Moayyeri, Liesbeth Vandenput, Dana Willner, Su-Mei Xiao, Jbj Van Meurs, Hou-Feng Zheng, Fmk Williams, Nerea Alonso, Joel Eriksson, Ar Wood, Gudmar Thorleifsson, Fa Tylavsky, Cm Van Duijn, Nj Wareham, Ag Uitterlinden, El Duncan, Ville Aalto, Markku Alen, Ome Albagha, Thor Aspelund, Jacqueline R. Center, Zoe Dailiana, Jp Kemp, Melissa Garcia, Natalia Garcia-Giralt

, Sylvie Giroux, Goran Hallmans, Dl Koller, Rl Minster, Rita Khusainova, Cm Kammerer, Charles Kooperberg, Theodora Koromila, Marcin Kruk, Sk Kaptoge, Marika Laaksonen, Pj Leo, Ak Aragaki, Joshua R . Lewis, Laura Masi, Simona Mencej-Bedrac, Xavier Nogues, Dj Duggan, Millan S. Patel, Janez Prezelj, Serena Scollen, Kristin Siggeirsdottir, Lj Hocking, Olle Svensson, Stella Trompet, Olivia Trummer, Natasja M. van Schoor, Jean Woo, Kun Zhu, Lb Husted, Ka Jameson, Susana Balcells, Gs Kim, Az Lacroix, Sulin Cheng, Claus Christiansen, Sh Lee, Cyrus Cooper, George Dedoussis, Ian Ford, Morten Frost, Pc Leung, David Goltzman, Jesus González-Macías, Mika Kähönen

, Magnus Karlsson, Elza Khusnutdinova, Jung-Min Koh, Panagoula Kollia, Tv Nguyen, Lm Rose, Paul Lips, Osten Ljunggren, Av Smith

, Janja Marc, Dan Mellström, Barbara Obermayer-Pietsch, Mika Kahonen, Ulrika Pettersson-Kymmer, Ml Brandi, Francois Rousseau, Pes Eline S. Lagboom, Roser Urreizti, Bm Buckley, Wim Van Hul, Jorma Viikari, P. Eline Slagboom, Bl Langdahl, Wd Leslie, Martha Castano-Betancourt, Rs Lorenc, Elin Grundberg, Lizbeth Herrera, Thorvaldur Ingvarsson, Hrefna Johannsdottir, Tony Kwan, Rui Li, Robert Luben

, Carolina Medina-Gómez

, Stefan Th Palsson, Jm Olmos, Sjur Reppe, Gunnar Sigurdsson, Joyce B. J. van Meurs, Dm Reid, Dominique Verlaan, Ja Riancho, Yanhua Zhou, Pm Ridker, Stefan Th Palsson, Tomi Pastinen, Soumya Raychaudhuri, Ys Aulchenko, Ji Rotter, Steven R. Cummings, Km Gautvik, Patrick Danoy, Ja Cauley

, Richard Eastell, Di Chasman, Vilmundur Gudnason, Albert Hofman, Gr Clark, Graeme Jones, Jw Wouter Jukema, Em Dennison, Kay-Tee Khaw, Terho Lehtimäki, Yongmei Liu, Mattias Lorentzon, Eugene Mccloskey, Ja Eisman, Kannabiran Nandakumar, Ben A. Oostra, Rd Jackson, Munro Peacock, Olli Raitakari, Bd Mitchell, John Robbins, Gc Nicholson, Hap Pols, Rl Prince, Ir Reid, Cornelia M. van Duijn, Pn Sambrook, Pc Sham, La Adrienne Cupples

, Ar Shuldiner, Mj Econs, Dm Evans, Tb Harris, Awc Kung, Jonathan Reeve, Bm Psaty, Mc Carola Zillikens, Unnur Thorsteinsdottir, Td Spector, Ea Streeten, Claes Ohlsson, David Karasik, Jb Brent Richards, Matthew A. Brown, Kari Stefansson, Sh Ralston, Jpa Ioannidis, Dp Kiel

, van Wim Hul, Fernando Rivadeneira

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Abstract

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P

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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Abstract