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Oxford University Press, Nucleic Acids Research, 15(32), p. e121-e121, 2004

DOI: 10.1093/nar/gnh120

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Genomic representations using concatenates of type IIB restriction endonuclease digestion fragments

Journal article published in 2004 by Thomas LaFramboise, Jianhua Zhang, Robert B. Den, David N. Hayes, Saikat DebRoy, Torstein Tengs, Robert C. Gentleman, Keith O'Neill, Bruce Birren, Matthew Meyerson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the fragments generated by cleavage with these enzymes. Here, we show that the RECORD libraries may be used for digital karyotyping and for pathogen identification by computational subtraction.