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EMBO Press, The EMBO Journal, 5(31), p. 1177-1189, 2012

DOI: 10.1038/emboj.2011.493

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ATR maintains select progenitors during nervous system development

Journal article published in 2012 by Youngsoo Lee, Erin Rp Shull, Pierre-Olivier Frappart ORCID, Sachin Katyal, Vanessa Enriquez-Rios, Jingfeng Zhao, Helen R. Russell, Eric J. Brown, Peter J. McKinnon
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This paper is available in a repository.

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Abstract

ATR kinase acts as a safeguard against replication stress, and hypomorphic mutations result in the neurodevelopmental disorder Seckel syndrome. Conditional ATR deletion in developing neurons reveals a selective role in maintenance of only a subset of neuronal progenitors, which may be distinct from ATR's canonical DNA damage-response roles.