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BioMed Central, Molecular Cancer, 1(10), p. 38

DOI: 10.1186/1476-4598-10-38

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The functional role of long non-coding RNA in human carcinomas

Journal article published in 2011 by Ewan A. Gibb, Carolyn J. Brown ORCID, Wan L. Lam
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.