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EMBO Press, EMBO Reports, 10(4), p. 939-943, 2003

DOI: 10.1038/sj.embor.embor921

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The ribosome and YidC

Journal article published in 2003 by Jan‐Willem L. de Gier, Joen Luirink ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the signal recognition particle pathway to the Sec translocon, which is capable of both linear transport into the periplasm and lateral transport into the lipid bilayer. Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly.